Human-centered models
We employ human intestinal organoids and cancer models to study human disease-relevant processes. These models enable mapping of the molecular and cellular phenotypes directly in …
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Singe-cell technologies
We develop and apply single-cell genomics and transcriptomics tools to dissect complex tissues at high resolution – focusing on joint measurements of DNA and RNA. These …
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Genetic variation
We investigate the generation and functional consequences of somatic mosaicism within tissues, with a focus on variation in the mitochondrial DNA. By mapping genotype-to-phenotype …
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