Genetic variation
We investigate the generation and functional consequences of somatic mosaicism within tissues, with a focus on variation in the mitochondrial DNA. By mapping genotype-to-phenotype relationships, we study how mutations shape cellular behavior in both health and disease.
Singe-cell technologies
We develop and apply single-cell genomics and transcriptomics tools to dissect complex tissues at high resolution – focusing on joint measurements of DNA and RNA. These technologies enable the identification of rare events, clonal dynamics, and the genetic diversity.
Human-centered models
We employ human intestinal organoids and cancer models to study human disease-relevant processes. These models enable mapping of the molecular and cellular phenotypes directly in human tissue biology, bridging the gap between experimental studies and clinical relevance.
Experimental savant?
We want you!
Computational genius?
We're recruiting
We are looking for motivated students interested in exploring how genetic variation shapes cellular function.
We welcome students from diverse backgrounds, including:
- Molecular/cell Biology
- Computational biology
- Physics/Mathematics/Computer Science
In the lab, you will have the opportunity to:
- Work on interdisciplinary projects combining experiments and computation
- Develop skills in single-cell genomics and data analysis
- Contribute to developing new experimental and computational tools
- Be part of a collaborative and supportive research environment
If you are interested in joining the lab, please send a short statement of interest and your CV.
